Our laboratory takes molecular approaches to herpesvirus replication and latency. These studies provide excellent models for biological processes in eukaryotic cells and, because herpesviruses such as herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are important pathogens, to exploit differences between herpesvirus and cellular processes for safe and effective antiviral therapy. Areas of research include:
Novel post-transcriptional regulatory mechanisms. Current projects focus on the roles of viral microRNAs and unusual translational mechanisms during HSV infection.