Department of
Biological Chemistry & Molecular Pharmacology

Transcription and gene regulation

Stephen Buratowski

Professor
Telephone: 
617- 432-0696
Fax: 
617-738-0516
Address: 
Room C1 - 210
Address: 
240 Longwood Avenue
Address: 
Boston MA 02115

Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII) basal transcription factors, (B) the communication between chromatin and the transcription machinery, and (C) mRNA processing enzymes and their interactions with RNApII. Using the yeast Saccharomyces cerevisiae, a combination of biochemical and genetic techniques are being brought to bear on these questions. Several dozen proteins are required simply to initiate transcription, and many more are required for processes linked to transcription. Therefore, it is now necessary to decipher the functions of each of the individual factors. Some of our recent projects:

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David Fisher

Professor
Telephone: 
617-632-4916
Fax: 
617- 632-2085
Address: 
Room Dana-630, DFCI
Address: 
44 Binney St.
Address: 
Boston, MA 02215

Our group studies cell death/proliferation signals in relation to development and disease, particularly cancer. We attempt to understand critical modes of cell homeostasis with a goal of molecular targeted therapy for human disease.

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Stephen C. Harrison

Professor
Telephone: 
617-432-5609
Fax: 
617-432-5600
Address: 
Room SGM - 130
Address: 
250 Longwood Avenue
Address: 
Boston MA 02115

We are structural biologists concerned with the organization and dynamics of macromolecular assemblies. We ask the following kinds of questions. (1) How do viruses assemble and get into and out of cells? (2) What are the molecular mechanisms of vesicular membrane traffic, particularly in the clathrin-coated vesicle pathway? (3) What is the molecular architecture of a kinetochore and how does this architecture embody its required mechanical and signal-transducing properties?

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Andrew Lassar

Professor
Telephone: 
617- 432-3831
Fax: 
617-738-0516
Address: 
Room C1 -303
Address: 
240 Longwood Avenue
Address: 
Boston, MA 02115

Current work in my lab focuses on the signals and transcription factors that maintain skeletal muscle stem cells, the transcriptional regulatory pathways that regulates chondrocyte formation and maturation, and the development of a gene therapy model to treat osteoarthritis:
 

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Kevin Struhl

Professor
Telephone: 
617-432- 2104
Fax: 
617-432- 2529
Address: 
Room C1-315
Address: 
240 Longwood Ave.
Address: 
Boston, MA 02215

The molecular mechanisms of transcriptional regulation are highly conserved among eukaryotes. Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-binding activators and repressors on components of the general transcription machinery and chromatin modifying activities. Much of the work in this laboratory combines genetic, molecular, and genomic approaches available in yeast to address fundamental questions about transcriptional regulatory mechanisms in living cells. In addition, we are defining physiological targets of human transcriptional regulatory proteins and chromatin modifications on a whole-genome basis using a novel microarray approach.

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Timur Yusufzai

Assistant Professor
Telephone: 
617-582-9214
Fax: 
617-582-8213
Address: 
Dana Farber Cancer Institute
Address: 
Jimmy Fund Building, Room 520
Address: 
450 Brookline Ave.
Address: 
Boston, MA 02215

My lab uses a combination of biochemical and cell-based approaches to study factors involved in chromatin and DNA dynamics, with an emphasis on human disease models.  We are particularly interested in ATP-driven motor proteins such as chromatin remodeling enzymes, helicases, and the recently discovered annealing helicases.

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