Department of
Biological Chemistry & Molecular Pharmacology

Technology development

Haribabu Arthanari

Assistant Professor
Telephone: 
617-632-6422
Address: 
Longwood Center
Address: 
LC-3311
Address: 
360 Longwood Ave.
Address: 
Boston, MA 02115

   Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of unique structural landscapes as potential targets.

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Piotr Sliz

Associate Professor
Telephone: 
617-432-5608, ext 70
Fax: 
617-432-5600
Address: 
Seeley G. Mudd Bldg., Rm SGM-130
Address: 
250 Longwood Ave
Address: 
Boston, MA 02115

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues.

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Wesley P. Wong

Assistant Professor
Telephone: 
617-713-8383
Fax: 
617-713-8393
Address: 
Immune Disease Institute
Address: 
Harvard Medical School Affiliate
Address: 
3 Blackfan Circle, 3rd floor
Address: 
Boston, MA 02115

We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role of mechanical force. More specifically, we investigate how force regulates the structure and dynamics of interactions between and within single-molecules, and how this in turn can affect the functioning and malfunctioning of biological systems. To accomplish this, my group develops and applies novel tools in single-molecule manipulation and detection, combining approaches from a variety of disciplines, including physics, molecular biology, chemistry, and engineering. Some key research projects that we are working on are highlighted below.

1. Novel high-throughput methods in single-molecule manipulation, including single-molecule centrifugation

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