Department of
Biological Chemistry & Molecular Pharmacology

RNA-protein interactions

James M. Hogle

Professor
Telephone: 
617-432- 3918
Fax: 
617-432- 4360
Address: 
Room C-122
Address: 
250 Longwood Avenue
Address: 
Boston MA 02115

Our laboratory uses structural approaches to explore how viruses enter cells and replicate. Current research in the laboratory is focused in two areas: 1) a multiscaled approach to characterizing the cell entry pathway of poliovirus and other simple nonenveloped viruses, 2) structural studies of key proteins in the replication of herpes viruses (in collaboration with Don Coen) and poliovirus and it close relatives.

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Piotr Sliz

Associate Professor
Telephone: 
617-432-5608, ext 70
Fax: 
617-432-5600
Address: 
Seeley G. Mudd Bldg., Rm SGM-130
Address: 
250 Longwood Ave
Address: 
Boston, MA 02115

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues.

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