Department of
Biological Chemistry & Molecular Pharmacology

RNA processing

Stephen Buratowski

Professor
Telephone: 
617- 432-0696
Fax: 
617-738-0516
Address: 
Room C1 - 210
Address: 
240 Longwood Avenue
Address: 
Boston MA 02115

Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII) basal transcription factors, (B) the communication between chromatin and the transcription machinery, and (C) mRNA processing enzymes and their interactions with RNApII. Using the yeast Saccharomyces cerevisiae, a combination of biochemical and genetic techniques are being brought to bear on these questions. Several dozen proteins are required simply to initiate transcription, and many more are required for processes linked to transcription. Therefore, it is now necessary to decipher the functions of each of the individual factors. Some of our recent projects:

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Piotr Sliz

Associate Professor
Telephone: 
617-432-5608, ext 70
Fax: 
617-432-5600
Address: 
Seeley G. Mudd Bldg., Rm SGM-130
Address: 
250 Longwood Ave
Address: 
Boston, MA 02115

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues.

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