We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role of mechanical force. More specifically, we investigate how force regulates the structure and dynamics of interactions between and within single-molecules, and how this in turn can affect the functioning and malfunctioning of biological systems. To accomplish this, my group develops and applies novel tools in single-molecule manipulation and detection, combining approaches from a variety of disciplines, including physics, molecular biology, chemistry, and engineering. Some key research projects that we are working on are highlighted below.
1. Novel high-throughput methods in single-molecule manipulation, including single-molecule centrifugation