Department of
Biological Chemistry & Molecular Pharmacology

Immunology

David Golan

Professor
Telephone: 
617- 432- 2256
Fax: 
617-432- 3833
Address: 
Room SGM - 304C
Address: 
240 Longwood Avenue
Address: 
Boston MA 02115

Our goals are to understand the molecular interactions controlling protein and lipid mobility and distribution in cell membranes, the roles these mechanisms play in interactions between cells, and the relationships between derangements in these mechanisms and the pathophysiology of disease. We have designed and constructed several time-resolved scanning laser microscopes for interactive monitoring, tracking, and manipulating of biological samples at the single-cell and single-molecule levels on the µs-ms time scale and nm distance scale. Using these instruments, we are investigating: 1) Molecular interactions in erythroid cell membranes.

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Gerhard Wagner

Professor
Telephone: 
617-432- 3213
Fax: 
617-432- 4383
Address: 
Room C1-112
Address: 
240 Longwood Ave.
Address: 
Boston, MA 02215

Our research is concerned with structures of proteins and protein complexes. We use NMR spectroscopy, computational tools and small molecule inhibitors to study function and cellular significance of protein interactions.

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Hao Wu

Professor
Telephone: 
617-713-8160
Fax: 
617-713-8161
Address: 
Center for Life Sciences Boston (CLSB), Rm. 3099
Address: 
Three Blackfan Circle
Address: 
Boston, MA 02115

The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors. The lab began its studies on the signaling of a classical cytokine produced by the innate immune system, tumor necrosis factor (TNF), which induces diverse cellular responses such as NF-κB activation and cell death. Receptors for TNF belong to the large TNF receptor (TNFR) superfamily. The second pursuit of the lab has been the Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) superfamily, which induces signaling pathways overlapping with those of the TNFR superfamily.

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