Our research focuses on the molecular mechanism of membrane channels, receptors, and transporters. We have been using solution NMR spectroscopy to study these proteins, while pushing the technological envelope to enable NMR characterization of the structure and dynamics of more complex membrane systems.
Currently, my lab has three major aspects of research. One aspect is the structure and mechanism of viral ion channels. Our recent work on influenza proton channels have established a general NMR approach for characterizing the structures of viral channels, and for understanding the structural basis of drug inhibition and drug resistance. The long term goal is to develop novel antiviral therapeutics that target these viral channels.