Department of
Biological Chemistry & Molecular Pharmacology

Immune receptor assembly

James Chou

Professor
Telephone: 
617-432-2920
Fax: 
617-432-2921
Address: 
Room SGM- 109A
Address: 
250 Longwood Avenue
Address: 
Boston MA 02115

Our research focuses on the molecular mechanism of membrane channels, receptors, and transporters. We have been using solution NMR spectroscopy to study these proteins, while pushing the technological envelope to enable NMR characterization of the structure and dynamics of more complex membrane systems. 



Currently, my lab has three major aspects of research. One aspect is the structure and mechanism of viral ion channels. Our recent work on influenza proton channels have established a general NMR approach for characterizing the structures of viral channels, and for understanding the structural basis of drug inhibition and drug resistance. The long term goal is to develop novel antiviral therapeutics that target these viral channels.

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Hao Wu

Professor
Telephone: 
617-713-8160
Fax: 
617-713-8161
Address: 
Center for Life Sciences Boston (CLSB), Rm. 3099
Address: 
Three Blackfan Circle
Address: 
Boston, MA 02115

The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors. The lab began its studies on the signaling of a classical cytokine produced by the innate immune system, tumor necrosis factor (TNF), which induces diverse cellular responses such as NF-κB activation and cell death. Receptors for TNF belong to the large TNF receptor (TNFR) superfamily. The second pursuit of the lab has been the Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) superfamily, which induces signaling pathways overlapping with those of the TNFR superfamily.

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