Department of
Biological Chemistry & Molecular Pharmacology

Hematopoiesis

Alan D. D'Andrea

Professor
Telephone: 
617- 632-2112
Fax: 
617- 632-5757
Address: 
Room 640, Mayer Building, DFCI
Address: 
44 Binney Street
Address: 
Boston , MA 02115

Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by germline or somatic mutation, leads to genomic instability, cellular sensitivity to ionizing radiation, and defective cell cycle checkpoints and DNA repair. These pathways are often disrupted in cancer cells, accounting for the chromosome instability and increased mutation frequency in human tumors.

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George Daley

Professor
Telephone: 
617-919-2015
Fax: 
617-730-0222
Address: 
Children's Hospital
Address: 
300 Longwood Ave.
Address: 
Boston, MA 02115

The laboratory focuses on stem cell biology, with an emphasis on hematopoietic differentiation from human and mouse pluripotent stem cells (embryonic stem, ES, and induced Pluirpotent Stem, iPS) cells, epigenetic reprogramming, germ cell development, and the overlap between germ cells, stem cells and cancer. Our goals are described briefly below:

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