Department of
Biological Chemistry & Molecular Pharmacology

Enzyme mechanisms and chemistry of biomolecules

Jon Clardy

Professor
Telephone: 
617-432-2845
Fax: 
617-738-3702
Address: 
Room C-643
Address: 
240 Longwood Avenue
Address: 
Boston, MA 02115

The laboratory focuses on biologically active small molecules, especially those from bacteria and fungi with an overall goal of understanding how small molecules control biological processes.  Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in microbial symbioses , 2) function-based discovery of biologically active small molecules using high-throughput screening,  3) genome-based discovery of bacterially-produced small molecules.  The laboratory is also involved in infectious disease research and current projects include developing a high-throughput screen for small molecules that influence the liver stage of malaria.  

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Don Coen

Professor
Telephone: 
617-432-1691
Fax: 
617-432- 3833
Address: 
Room SGM - 304
Address: 
250 Longwood Avenue
Address: 
Boston MA 02115

Our laboratory takes molecular approaches to herpesvirus replication and latency.  These studies provide excellent models for biological processes in eukaryotic cells and, because herpesviruses such as herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are important pathogens, to exploit differences between herpesvirus and cellular processes for safe and effective antiviral therapy.   Areas of research include:

Novel post-transcriptional regulatory mechanisms.  Current projects focus on the roles of viral microRNAs and unusual translational mechanisms during HSV infection. 

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Michael Eck

Professor
Telephone: 
617-632-5860
Fax: 
617-632-4393
Address: 
Longwood Center, 4313
Address: 
360 Longwood Avenue
Address: 
Boston, MA 02215

Our laboratory studies the structural biology of cell signaling and the actin cytoskeleton. Active areas of investigation include: 1) the structure and regulation of focal adhesion kinase, 2) the molecular mechanisms that drive recruitment and activation of Src-family kinases in T-cell activation, and 3) formin proteins and the mechanisms by which they carry out the regulated assembly of actin structures. Additionally, we are studying other signaling interactions that may be targets for development of anti-cancer drugs. These include b -catenin/Tcf-4 and the interaction of transcription factor activation domains with p300/CBP.

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Christopher T. Walsh

Professor Emeritus
Telephone: 
617-432-1715
Fax: 
617-432-0438
Address: 
Armenise Building, Room 616
Address: 
200 Longwood Avenue
Address: 
Boston, MA 02215

The broad area of interest to this laboratory is the molecular basis of biological catalysis with focus on the structure and function of enzymes. Much of the current focus is on the biosynthesis and mechanism of action of antibiotics and bacterial siderophores.  The goal is to decipher the chemical mechanism of novel transformations in the assembly of bioactive small molecules

Four recent review articles which illustrate some of the group’s interests and approaches are listed below.

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