Department of
Biological Chemistry & Molecular Pharmacology

DNA Replication

Don Coen

Professor
Telephone: 
617-432-1691
Fax: 
617-432- 3833
Address: 
Room SGM - 304
Address: 
250 Longwood Avenue
Address: 
Boston MA 02115

Our laboratory takes molecular approaches to herpesvirus replication and latency.  These studies provide excellent models for biological processes in eukaryotic cells and, because herpesviruses such as herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are important pathogens, to exploit differences between herpesvirus and cellular processes for safe and effective antiviral therapy.   Areas of research include:

Novel post-transcriptional regulatory mechanisms.  Current projects focus on the roles of viral microRNAs and unusual translational mechanisms during HSV infection. 

» Read more...

Joseph Loparo

Associate Professor
Telephone: 
617-432-5586
Fax: 
617-738-0516
Address: 
Room SGM-204A
Address: 
240 Longwood Ave.
Address: 
Boston, MA 02115

Single-Molecule Studies of DNA Damage Tolerance and Repair

» Read more...

Charles C. Richardson

Professor
Telephone: 
617-432-1864
Fax: 
617-432-3362
Address: 
Room C2-219
Address: 
240 Longwood Avenue
Address: 
Boston MA 02115

Fig. 1A major goal is to define, in molecular terms, the mechanism by which a chromosome is replicated. The replication of the chromosome of bacteriophage T7 has been used as a model system.  T7 has evolved an efficient and economical system for DNA replication.  The cartoon depicts the T7 replisome and illustrates the major molecular motors and contacts. On the leading strand, T7 DNA polymerase (gp5) undergoes multiple conformational changes as it moves from one template position to another and senses the correct fit of an incoming deoxyribonucleoside triphosphate.  E.

» Read more...

Johannes Walter

Professor
Telephone: 
617-432-4799
Fax: 
617-738-0516
Address: 
Room C1-226A
Address: 
240 Longwood Ave.
Address: 
Boston, MA 02115

The chromosome replication cycle
My lab uses a model cell-free system derived from Xenopus eggs to study how genetic information is faithfully transmitted from one cell generation to the next. We are interested in the following questions:

1. How is DNA replication coordinated with the cell cycle?

» Read more...

Timur Yusufzai

Assistant Professor
Telephone: 
617-582-9214
Fax: 
617-582-8213
Address: 
Dana Farber Cancer Institute
Address: 
Jimmy Fund Building, Room 520
Address: 
450 Brookline Ave.
Address: 
Boston, MA 02215

My lab uses a combination of biochemical and cell-based approaches to study factors involved in chromatin and DNA dynamics, with an emphasis on human disease models.  We are particularly interested in ATP-driven motor proteins such as chromatin remodeling enzymes, helicases, and the recently discovered annealing helicases.

» Read more...