Department of
Biological Chemistry & Molecular Pharmacology

Chromatin modifications

Stephen Buratowski

Professor
Telephone: 
617- 432-0696
Fax: 
617-738-0516
Address: 
Room C1 - 210
Address: 
240 Longwood Avenue
Address: 
Boston MA 02115

Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII) basal transcription factors, (B) the communication between chromatin and the transcription machinery, and (C) mRNA processing enzymes and their interactions with RNApII. Using the yeast Saccharomyces cerevisiae, a combination of biochemical and genetic techniques are being brought to bear on these questions. Several dozen proteins are required simply to initiate transcription, and many more are required for processes linked to transcription. Therefore, it is now necessary to decipher the functions of each of the individual factors. Some of our recent projects:

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