Department of
Biological Chemistry & Molecular Pharmacology

Cell cycle and cell division

Elaine Elion

Professor
Telephone: 
617-432-3815
Fax: 
617-738-0516
Address: 
Room C1-302
Address: 
240 Longwood Avenue
Address: 
Boston MA 02115

Our group studies eukaryotic signal transduction, focusing on how external stimuli control proliferation, differentiation, and homeostasis. Work has centered on defining how mitogen activated protein kinase (MAPK) cascades function in vivo. MAPK cascades form the cores of numerous eukaryotic signal transduction pathways that control growth, differentiation and survival. Misregulation of MAPK cascades is associated with a variety of diseases, including cancer. We use a yeast model system (Figure 1) and genetic, biochemical and cell biological approaches.

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Ed Harlow

Professor

Research in the Harlow laboratory focuses on new approaches for functional analysis in mammalian cells. Our primary interest is learning how to do high throughput and unbiased screens for genes that affect key phenotypes of cancer biology. The levels of specific proteins can be increased or decreased by expressing the protein itself from a cDNA copy or by the introduction of an inhibitory RNA for the mRNA. We use libraries of individually cloned and sequenced full length coding regions and siRNAs to raise or lower protein levels in cells and study changes in cellular phenotypes. At present we have a complete proteome for several test organisms—bacteria Pseudomonas aeruginosa, the yeast Saccharomyces cerevisiae, and libraries for several viruses.

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Andrew Lassar

Professor
Telephone: 
617- 432-3831
Fax: 
617-738-0516
Address: 
Room C1 -303
Address: 
240 Longwood Avenue
Address: 
Boston, MA 02115

Current work in my lab focuses on the signals and transcription factors that maintain skeletal muscle stem cells, the transcriptional regulatory pathways that regulates chondrocyte formation and maturation, and the development of a gene therapy model to treat osteoarthritis:
 

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Joseph Loparo

Associate Professor
Telephone: 
617-432-5586
Fax: 
617-738-0516
Address: 
Room SGM-204A
Address: 
240 Longwood Ave.
Address: 
Boston, MA 02115

Single-Molecule Studies of DNA Damage Tolerance and Repair

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Johannes Walter

Professor
Telephone: 
617-432-4799
Fax: 
617-738-0516
Address: 
Room C1-226A
Address: 
240 Longwood Ave.
Address: 
Boston, MA 02115

The chromosome replication cycle
My lab uses a model cell-free system derived from Xenopus eggs to study how genetic information is faithfully transmitted from one cell generation to the next. We are interested in the following questions:

1. How is DNA replication coordinated with the cell cycle?

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