Department of
Biological Chemistry & Molecular Pharmacology

Biophysics

Haribabu Arthanari

Assistant Professor
Telephone: 
617-632-6422
Address: 
Longwood Center
Address: 
LC-3311
Address: 
360 Longwood Ave.
Address: 
Boston, MA 02115

   Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of unique structural landscapes as potential targets.

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Andrew Kruse

Assistant Professor
Telephone: 
617-432-3252
Address: 
Department of Biological Chemistry & Molecular Pharmacology
Address: 
Harvard Medical School
Address: 
240 Longwood Avenue
Address: 
Building C, Room 202
Address: 
Boston, MA 02115

Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying transmembrane signaling remain poorly understood. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology. In particular, we are focused on the study of proteins important in human health and disease, including G protein-coupled receptors and other proteins that regulate neurotransmission and metabolic homeostasis.

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Wesley P. Wong

Assistant Professor
Telephone: 
617-713-8383
Fax: 
617-713-8393
Address: 
Immune Disease Institute
Address: 
Harvard Medical School Affiliate
Address: 
3 Blackfan Circle, 3rd floor
Address: 
Boston, MA 02115

We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role of mechanical force. More specifically, we investigate how force regulates the structure and dynamics of interactions between and within single-molecules, and how this in turn can affect the functioning and malfunctioning of biological systems. To accomplish this, my group develops and applies novel tools in single-molecule manipulation and detection, combining approaches from a variety of disciplines, including physics, molecular biology, chemistry, and engineering. Some key research projects that we are working on are highlighted below.

1. Novel high-throughput methods in single-molecule manipulation, including single-molecule centrifugation

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Hao Wu

Professor
Telephone: 
617-713-8160
Fax: 
617-713-8161
Address: 
Center for Life Sciences Boston (CLSB), Rm. 3099
Address: 
Three Blackfan Circle
Address: 
Boston, MA 02115

The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors. The lab began its studies on the signaling of a classical cytokine produced by the innate immune system, tumor necrosis factor (TNF), which induces diverse cellular responses such as NF-κB activation and cell death. Receptors for TNF belong to the large TNF receptor (TNFR) superfamily. The second pursuit of the lab has been the Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) superfamily, which induces signaling pathways overlapping with those of the TNFR superfamily.

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