Christopher T. Walsh
The broad area of interest to this laboratory is the molecular basis of biological catalysis with focus on the structure and function of enzymes. Much of the current focus is on the biosynthesis and mechanism of action of antibiotics and bacterial siderophores. The goal is to decipher the chemical mechanism of novel transformations in the assembly of bioactive small molecules
Four recent review articles which illustrate some of the group’s interests and approaches are listed below.
Elizabeth Sattely, Michael Fischbach, Christopher T Walsh  Total Biosynthesis: in vitro reconstitution of Polyketide and Nonribosomal peptide pathways. Natural Product Reports, 25, 757-793
Elizabeth Nolan, Christopher Walsh  How Nature Morphs Peptide Scaffolds into Antibiotics. ChemBiochem, 10, 34-53
Michael Fischbach, Christopher T Walsh,  Antibiotics for Emerging Pathogens Science, 325, 1089-1093
Christopher T Walsh, Michael A Fischbach  Natural Products Version 2.0. Connecting Genes to Molecules, JACS, 132, 2469-93