Department of
Biological Chemistry & Molecular Pharmacology

Christopher T. Walsh

Professor Emeritus
Armenise Building, Room 616
200 Longwood Avenue
Boston, MA 02215
Research Areas

The broad area of interest to this laboratory is the molecular basis of biological catalysis with focus on the structure and function of enzymes. Much of the current focus is on the biosynthesis and mechanism of action of antibiotics and bacterial siderophores.  The goal is to decipher the chemical mechanism of novel transformations in the assembly of bioactive small molecules

Four recent review articles which illustrate some of the group’s interests and approaches are listed below.


Elizabeth Sattely, Michael Fischbach, Christopher T Walsh [2008] Total Biosynthesis: in vitro reconstitution of Polyketide and Nonribosomal peptide pathways. Natural Product Reports, 25, 757-793

Elizabeth Nolan, Christopher Walsh [2009] How Nature Morphs Peptide Scaffolds into Antibiotics. ChemBiochem, 10, 34-53

Michael Fischbach, Christopher T Walsh, [2009] Antibiotics for Emerging Pathogens Science, 325, 1089-1093

Christopher T Walsh, Michael A Fischbach [2010] Natural Products Version 2.0. Connecting Genes to Molecules, JACS, 132, 2469-93