Department of
Biological Chemistry & Molecular Pharmacology

Shobha Vasudevan

Assistant Professor
Address: 
Massachusetts General Hospital
Address: 
CPZN 4100/4202
Address: 
185 Cambridge Street
Address: 
Boston, MA 02114

MicroRNAs are small non-coding RNAs that target distinct RNAs while AU-rich elements (AREs) are highly conserved mRNA 3’ untranslated region (UTR) regulatory elements that control post-transcriptional gene expression of clinically relevant messages, including those of cytokines and potent growth factors. Recent evidences implicate microRNAs in ARE-mediated post-transcriptional regulation. MicroRNAs, like AREs, are known post-transcriptional regulators in cell proliferation, development and death; their deregulation lead to rapid and dramatic changes in expression levels promoting a broad range of critical effects, in particular, tumor growth, angiogenesis and metastasis, several types of leukemias, lymphomas and developmental disorders.

Publications: 

Mortensen RD*, Serra M*, Steitz JA and Vasudevan S. (2011). Post-transcriptional activation of gene expression in Xenopus laevis oocytes by microRNPs. PNAS. In press.

Vasudevan S, and Steitz JA. (2007). AU-rich element-mediated upregulation of translation by FXR1 and Argonaute2. Cell. 128: 1105-1118.

Vasudevan S, Tong Y and Steitz JA. (2007). Switching between repression and activation: microRNAs can activate translation. Science. 318: 1931-1934.

Vasudevan S, Tong Y, and Steitz JA. (2008). Cell-cycle control of microRNA-mediated translation regulation, Cell Cycle. 7:11, 1545-1549.

Steitz JA, and Vasudevan S. (2009). MicroRNPs: Versatile regulators of gene expression in vertebrate cells. Biochemical Society Transactions, 37(Pt 5):931-5.

View a list of publications by researchers at the Vasudevan Laboratory