MicroRNAs are small non-coding RNAs that target distinct RNAs while AU-rich elements (AREs) are highly conserved mRNA 3’ untranslated region (UTR) regulatory elements that control post-transcriptional gene expression of clinically relevant messages, including those of cytokines and potent growth factors. Recent evidences implicate microRNAs in ARE-mediated post-transcriptional regulation. MicroRNAs, like AREs, are known post-transcriptional regulators in cell proliferation, development and death; their deregulation lead to rapid and dramatic changes in expression levels promoting a broad range of critical effects, in particular, tumor growth, angiogenesis and metastasis, several types of leukemias, lymphomas and developmental disorders.
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